小鼠抗ESR1单克隆抗体

Background:

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Applications:

WB, IHC

Name of antibody:

ESR1

Immunogen:

Fusion protein of human ESR1

Full name:

estrogen receptor 1 (ESR1), transcript variant 1

Synonyms:

ER; Era; ESR; ESRA; ESTRR; NR3A1

SwissProt:

P03372

IHC positive control:

adenocarcinoma of human breast tissue and adenocarcinoma of human ovary tissue; human endometrium tissue and adenocarcinoma of human endometrium tissue

IHC Recommend dilution:

100-500

WB Predicted band size:

66 kDa

WB Positive control:

Hela, SVT2, A549, COS7, MDCK and MCF7 cell lysates

WB Recommended dilution:

500-2000