兔抗DUSP7多克隆抗体

Background:

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).

Applications:

ELISA, IHC

Name of antibody:

DUSP7

Immunogen:

Fusion protein of human DUSP7

Full name:

dual specificity phosphatase 7

Synonyms:

MKPX; PYST2

SwissProt:

Q16829

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil

IHC Recommend dilution:

50-300