兔抗DNAJA4多克隆抗体

Background:

The DnaJ family is one of the largest of all the chaperone families and has evolved with diverse cellular localization and functions. The presence of the J domain defines a protein as a member of the DnaJ family. DnaJ heat shock induced proteins are from the bacterium Escherichia coli and are under the control of the htpR regulatory protein. The DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. The proteins contain cysteine rich regions that are composed of zinc fingers that form a peptide binding domain responsible for the chaperone function. DnaJ proteins are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. DnaJA4 (DnaJ homolog subfamily A member 4) is a SREBP-regulated chaperone that is thought to regulate the cholesterol biosynthesis pathway.

Applications:

ELISA, WB, IHC

Name of antibody:

DNAJA4

Immunogen:

Fusion protein of human DNAJA4

Full name:

DnaJ heat shock protein family (Hsp40) member A4

Synonyms:

MST104; MSTP104; PRO1472

SwissProt:

Q8WW22

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and Human tonsil

IHC Recommend dilution:

50-200

WB Predicted band size:

45 kDa

WB Positive control:

TM4 cell lysate

WB Recommended dilution:

500-2000