兔抗COL25A1多克隆抗体

Background:

This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

COL25A1

Immunogen:

Synthetic peptide of human COL25A1

Full name:

collagen type XXV alpha 1

Synonyms:

AMY; CLAC; CLACP; CFEOM5; CLAC-P

SwissProt:

Q9BXS0

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

65 kDa

WB Positive control:

A549,Jurkat and A172 cell,Human testis tissue,Hela cell lysates

WB Recommended dilution:

200-1000