兔抗DENND1A多克隆抗体

Background:

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).

Applications:

ELISA, IHC

Name of antibody:

DENND1A

Immunogen:

Fusion protein of human DENND1A

Full name:

DENN domain containing 1A

Synonyms:

FAM31A; KIAA1608

SwissProt:

Q8TEH3

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil

IHC Recommend dilution:

50-200