XRCC6抗原（重组蛋白）

Full name:

X-ray repair complementing defective repair in Chinese hamster cells 6

Synonyms:

ML8, KU70, TLAA, CTC75, CTCBF, G22P1

Swissprot:

P12956

Gene Accession:

BC008343

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.