兔抗CYP2C8多克隆抗体

Background:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

CYP2C8

Immunogen:

Synthetic peptide corresponding to a region derived from 236-250 amino acids of human CYP2C8

Full name:

cytochrome P450 family 2 subfamily C member 8

Synonyms:

CPC8; CYPIIC8; MP-12/MP-20

SwissProt:

P10632

ELISA Recommended dilution:

500-1000

IHC Positive control:

Human esophagus cancer;Human brain

IHC Recommended dilution:

20-100