兔抗VASP多克隆抗体

Background:

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.

Applications:

ELISA, WB, IHC

Name of antibody:

VASP

Immunogen:

Fusion protein of human VASP

Full name:

vasodilator-stimulated phosphoprotein

SwissProt:

P50552

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil

IHC Recommend dilution:

25-100

WB Predicted band size:

40 kDa

WB Positive control:

A549 and HEPG2 cell lysates

WB Recommended dilution:

500-2000