小鼠抗TGM2单克隆抗体

Background:

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.

Applications:

WB, IHC

Name of antibody:

TGM2

Immunogen:

Fusion protein of human TGM2

Full name:

transglutaminase 2

Synonyms:

TGC; TG(C)

SwissProt:

P21980

IHC positive control:

Human lymphoma tissue

IHC Recommend dilution:

200-500

WB Predicted band size:

77 KD

WB Positive control:

Jurkat, Hela, A549, MCF7, HepG2 and HUVEC cell lysates

WB Recommended dilution:

500-2000