兔抗MYH7多克隆抗体

Background:

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.

Applications:

ELISA, IHC

Name of antibody:

MYH7

Immunogen:

Fusion protein of human MYH7

Full name:

myosin, heavy chain 7, cardiac muscle, beta

Synonyms：

CMH1, MPD1, SPMD, SPMM, CMD1S, MYHCB

SwissProt:

P12883

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human colon cancer

IHC Recommend dilution:

10-50