兔抗GDNF多克隆抗体

Background:

This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease.

Applications:

ELISA, WB

Name of antibody:

GDNF

Immunogen:

Fusion protein of human GDNF

Full name:

glial cell derived neurotrophic factor

Synonyms:

ATF1; ATF2; HSCR3; HFB1-GDNF

SwissProt:

P39905

ELISA Recommended dilution:

2000-5000

WB Predicted band size:

24 kDa

WB Positive control:

Mouse liver tissue lysate

WB Recommended dilution:

200-1000