兔抗CNOT2(Ab-101) 多克隆抗体

Background:

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.

Applications:

WB

Name of antibody:

CNOT2(Ab-101)

Immunogen:

Synthesized non-phosphopeptide derived from human CNOT2 around the phosphorylation site of serine 101 (S-L-S(p)-Q-G).

Full name:

CCR4-NOT transcription complex, subunit 2

Synonyms：

NOT2; CDC36; NOT2H; HSPC131

SwissProt:

Q9NZN8

WB Predicted band size:

60 kDa

WB Positive control:

HepG2 cells treated with starved (24hours) lysate

WB Recommended dilution:

500-3000