兔抗PIAS4多克隆抗体

Background:

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.

Applications:

WB, IHC

Name of antibody:

PIAS4

Immunogen:

Synthesized peptide derived from Internal of human PIAS4.

Full name:

protein inhibitor of activated STAT, 4

Synonyms：

PIASY; Piasg; ZMIZ6

SwissProt:

Q8N2W9

IHC positive control:

Human lung carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

57 kDa

WB Positive control:

Jurkat cells lysate

WB Recommended dilution:

500-3000