兔抗CHMP2B多克隆抗体

Background:

This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.

Applications:

ELISA, IHC

Name of antibody:

CHMP2B

Immunogen:

Fusion protein corresponding to a region derived from 94-213 amino acids of human CHMP2B

Full name:

charged multivesicular body protein 2B

Synonyms:

DMT1; ALS17; VPS2B; VPS2-2; CHMP2.5

SwissProt:

Q9UQN3

ELISA Recommended dilution:

5000-10000

IHC Positive control:

Human brain;Human esophagus cancer

IHC Recommended dilution:

20-100