兔抗NFKBIA (Phospho-Ser32 Ser36)多克隆抗体

Background:

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.

Applications:

WB, IHC, IF

Name of antibody:

NFKBIA (Phospho-Ser32/Ser36)

Immunogen:

Synthetic peptide of human NFKBIA (Phospho-Ser32/Ser36)

Full name:

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (Phospho-Ser32/Ser36)

Synonyms:

IKBA; MAD-3; NFKBI

SwissProt:

P25963

IHC positive control:

Human breast carcinoma

IHC Recommend dilution:

50-100

WB Predicted band size:

39 kDa

WB Positive control:

Hela cells untreated or treated with TNF

WB Recommended dilution:

500-1000

Positive control:

Hela cells

Recommended dilution:

100-200