兔抗CHCHD5多克隆抗体

Background:

CHCHD5 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 5) is a 110 amino acid protein that contains one CHCH domain. The gene encoding CHCHD5 maps to human chromosome 2, which consists of 237 million bases encoding over 1,400 genes and making up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr?m syndrome is due to mutations in the ALMS1 gene. Interestingly, chromosome 2 contains what appears to be a vestigial second centromere and vestigial telomeres which gives credence to the hypothesis that human chromosome 2 is the result of an ancient fusion of two ancestral chromosomes seen in modern form today in apes.

Applications:

ELISA, IHC

Name of antibody:

CHCHD5

Immunogen:

Full length fusion protein

Full name:

coiled-coil-helix-coiled-coil-helix domain containing 5

Synonyms:

MIC14; C2orf9

SwissProt:

Q9BSY4

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer and Human gastric cancer

IHC Recommend dilution:

20-100