小鼠抗RNF14单克隆抗体

Background:

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported.

Applications:

WB, IHC

Name of antibody:

RNF14

Immunogen:

Fusion protein of human RNF14

Full name:

ring finger protein 14

Synonyms:

ARA54; HFB30; TRIAD2; HRIHFB2038

SwissProt:

Q9UBS8

IHC positive control:

Human colorectal cancer and Human kidney tissue

IHC Recommend dilution:

200-500

WB Predicted band size:

54 KD

WB Positive control:

Jurkat, Hela, RAW264.7 cell lysates

WB Recommended dilution:

200-1000