小鼠抗RAB24单克隆抗体

Background:

The Ras-related superfamily of guanine nucleotide binding proteins, which includes the R-Ras, Rap, Ral/Rec and Rho/Rab superfamilies exhibit 30-60% homology with Ras p21. Accumulating data suggests an important role for Rab proteins, either in endocytosis or in biosynthetic protein transport. The transport of newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves at each stage the movement of carrier vesicles, a process that appears to involve Rab protein function. The possiblity that Rab proteins might also direct the exocytosis from secretory vesicles to the plasma membrane is supported by the observation that in yeast, the SEC4 protein, which is 40% homologous to Rab proteins, is associated with secretory vesicles. Rab 24 differs from other Rab family members because it has low intrinsic GTPase activity and is not efficiently prenylated. Rab 24 is thought to be involved in the autophagic pathway.

Applications:

WB, IF

Name of antibody:

RAB24

Immunogen:

Fusion protein of human RAB24

Full name:

RAB24, member RAS oncogene family (RAB24), transcript variant 1

Synonyms:

RAB24, member RAS oncogene family; RAB24 gene product

SwissProt:

Q969Q5

WB Predicted band size:

23 kDa

WB Positive control:

HepG2, Hela, SVT2, Jurkat, MDCK, MCF-7 cell lysates

WB Recommended dilution:

200-1000