兔抗ACO1多克隆抗体

Background:

Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

Applications:

ELISA, WB

Name of antibody:

ACO1

Immunogen:

Synthetic peptide of human ACO1

Full name:

aconitase 1, soluble

Synonyms：

IRP1; ACONS; IREB1; IREBP; IREBP1

SwissProt:

P21399

ELISA Recommended dilution:

2000-10000

WB Predicted band size:

98 kDa

WB Positive control:

Mouse liver tissue

WB Recommended dilution:

1000-5000