兔抗KCNJ11多克隆抗体

Background:

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Applications:

ELISA, IHC

Name of antibody:

KCNJ11

Immunogen:

Fusion protein of human KCNJ11

Full name:

potassium inwardly-rectifying channel, subfamily J, member 11

Synonyms：

BIR; HHF2; PHHI; IKATP; TNDM3; KIR6.2

SwissProt:

Q14654

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human colon cancer and human brain

IHC Recommend dilution:

50-200