兔抗IRF9多克隆抗体

Background:

Interferon regulatory factor 9 is a protein that in humans is encoded by the IRF9 gene, previously known as ISGF3G. Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Applications:

ELISA, WB

Name of antibody:

IRF9

Immunogen:

Fusion protein of human IRF9

Full name:

interferon regulatory factor 9

Synonyms：

p48; IRF-9; ISGF3; ISGF3G

SwissProt:

Q00978

ELISA Recommended dilution:

1000-2000

WB Predicted band size:

44 kDa

WB Positive control:

Mouse heart tissue

WB Recommended dilution:

200-1000