兔抗IFT57多克隆抗体

Background:

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.

Applications:

ELISA, IHC

Name of antibody:

IFT57

Immunogen:

Fusion protein of human IFT57

Full name:

intraflagellar transport 57

Synonyms:

HIPPI; MHS4R2; ESRRBL1

SwissProt:

Q9NWB7

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil

IHC Recommend dilution:

50-300