小鼠抗LCK单克隆抗体

Background:

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described.

Applications:

WB

Name of antibody:

LCK

Immunogen:

Fusion protein of human LCK

Full name:

LCK proto-oncogene, Src family tyrosine kinase

Synonyms:

LSK; YT16; IMD22; p56lck; pp58lck

SwissProt:

P06239

WB Predicted band size:

58 kDa

WB Positive control:

Ramos and Jurkat cell lysates

WB Recommended dilution:

1000-5000