小鼠抗GAD2单克隆抗体

Background:

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

Applications:

WB

Name of antibody:

GAD2

Immunogen:

Fusion protein of human GAD2

Full name:

glutamate decarboxylase 2

Synonyms:

GAD65

SwissProt:

Q05329

WB Predicted band size:

65 kDa

WB Positive control:

Rat Hippocampus and Rat Brain tissue lysates

WB Recommended dilution:

1000-5000