小鼠抗DTWD1单克隆抗体

Background:

DTWD1 (DTW domain-containing protein 1), also known as MDS009, is a 304 amino acid protein that contains one DXTW motif and belongs to the DTW family. Existing as three alternatively spliced isoforms, DTWD1 is encoded by a gene that maps to human chromosome 15q21.2. Chromosome 15 is made up of approximately 106 million base pairs and is about 3% of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region. In the case of Angelman syndrome, this loss is due to inactivity of the maternal 15q11-q13 encoded UBE3A gene in the brain by either chromosomal deletion or mutation. In cases of Prader-Willi syndrome, there is a partial or complete deletion of this region from the paternal copy of chromosome 15. Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene, which is encoded by chromosome 15. Marfan syndrome is associated with chromosome 15 through the FBN1 gene.

Applications:

WB, IHC

Name of antibody:

DTWD1

Immunogen:

Fusion protein of human DTWD1

Full name:

DTW domain containing 1

Synonyms:

MDS009

SwissProt:

Q8N5C7

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

200-500

WB Predicted band size:

35 KD

WB Positive control:

U251 cell lysate

WB Recommended dilution:

500-2000