兔抗ABL1ABL2(phospho-Tyr393439)多克隆抗体

Background:

Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

Applications:

WB, IHC, IF

Name of antibody:

ABL1/ABL2(phospho-Tyr393/439)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 393/439 (D-T-Y(p)-T-A) derived from Human ABL1/2.

Full name:

ABL proto-oncogene 1, non-receptor tyrosine kinase/ABL proto-oncogene 2, non-receptor tyrosine kinase

Synonyms:

ABL; JTK7; p150; c-ABL; v-abl; CHDSKM; c-ABL1; bcr/abl; ARG; ABLL

SwissProt:

P00519/P42684

IHC positive control:

Human breast carcinoma

IHC Recommend dilution:

50-100

WB Predicted band size:

210 kDa

WB Positive control:

HL60 cells

WB Recommended dilution:

500-1000

IF Positive control:

Hela cells

IF Recommended dilution:

100-200