小鼠抗COPS6单克隆抗体

Background:

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008].

Applications:

WB, IHC

Name of antibody:

COPS6

Immunogen:

Fusion protein of human COPS6

Full name:

COP9 signalosome subunit 6 (COPS6)

Synonyms:

CSN6; MOV34-34KD

SwissProt:

Q7L5N1

IHC positive control:

adenocarcinoma of human colon tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

36 kDa

WB Positive control:

HepG2, Hela, SVT2, A549, COS7, Jurkat, MDCK, PC12, MCF-7 cell lysates

WB Recommended dilution:

1000-5000