小鼠抗CASP9单克隆抗体

Background:

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

Applications:

WB

Name of antibody:

CASP9

Immunogen:

Fusion protein of human CASP9

Full name:

caspase 9

Synonyms:

MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6

SwissProt:

P55211

WB Predicted band size:

46 kDa

WB Positive control:

A549, MCF7, Jurkat, K562 and Hela cell lysates

WB Recommended dilution:

1000-5000