小鼠抗ARG2单克隆抗体

Background:

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described.

Applications:

WB, IHC, IF

Name of antibody:

ARG2

Immunogen:

Fusion protein of human ARG2

Full name:

arginase 2 (ARG2)

Synonyms:

L-arginine amidinohydrolase; L-arginine ureahydrolase; arginase 2; kidney arginase; nonhepatic arginase; arginase, type II

SwissProt:

P78540

IHC positive control:

human prostate tissue and adenocarcinoma of human colon tissue; carcinoma of human prostate tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

39 kDa

WB Positive control:

HepG2, Hela, Jurkat, MDCK, PC12 cell lysates

WB Recommended dilution:

500-2000