兔抗CENPH多克隆抗体

Background:

Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.

Applications:

ELISA, WB, IHC

Name of antibody:

CENPH

Immunogen:

Fusion protein of human CENPH

Full name:

centromere protein H

SwissProt:

Q9H3R5

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human cervical cancer and Human colorectal cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

28 kDa

WB Positive control:

Mouse lung tissue lysate

WB Recommended dilution:

500-2000