兔抗LILRB1多克隆抗体

Background:

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

LILRB1

Immunogen:

Fusion protein of human LILRB1

Full name:

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1

Synonyms:

ILT2; LIR1; MIR7; CD85J; ILT-2; LIR-1; MIR-7

SwissProt:

Q8NHL6

IHC positive control:

Human gastric cancer and human liver cancer

IHC Recommend dilution:

50-200