兔抗BCR (Phospho-Tyr177)多克隆抗体

Background:

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Applications:

WB, IHC

Name of antibody:

BCR (Phospho-Tyr177)

Immunogen:

Synthetic peptide of human BCR (Phospho-Tyr177)

Full name:

breakpoint cluster region (Phospho-Tyr177)

Synonyms：

ALL; CML; PHL; BCR1; D22S11; D22S662

SwissProt:

P11274

IHC positive control:

Human tonsil tumor

IHC Recommend dilution:

50-100

WB Predicted band size:

210 kDa

WB Positive control:

K562 cells untreated or treated with H2O2

WB Recommended dilution:

500-1000