兔抗TPMT多克隆抗体

Background:

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.

Applications:

ELISA, IHC

Name of antibody:

TPMT

Immunogen:

Fusion protein of human TPMT

Full name:

thiopurine S-methyltransferase

Synonyms:

TPMTD

SwissProt:

P51580

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human cervical cancer

IHC Recommend dilution:

40-200