兔抗LATS1/2(Phospho-Thr1079/1041) 多克隆抗体

Background:

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding.

Applications:

IHC

Name of antibody:

LATS1/2(Phospho-Thr1079/1041)

Immunogen:

Peptide sequence around phosphorylation site of threonine 1079/1041 (E-F-T(p)-F-R) derived from Human LATS1/2 .

Full name:

large tumor suppressor kinase 1/2

Synonyms：

wts; WARTS/KPM

SwissProt:

O95835/Q9NRM7

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100