兔抗GRAP多克隆抗体

Background:

This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.

Applications:

ELISA, IHC

Name of antibody:

GRAP

Immunogen:

Full length fusion protein

Full name:

GRB2-related adaptor protein

SwissProt:

Q13588

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human gastric cancer and human breast cancer

IHC Recommend dilution:

30-150