兔抗PTPN2多克隆抗体

Background:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported.

Applications:

WB

Name of antibody:

PTPN2

Immunogen:

Fusion protein of human PTPN2

Full name:

protein tyrosine phosphatase, non-receptor type 2

Synonyms：

PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP

SwissProt:

P17706

WB Predicted band size:

49 kDa

WB Positive control:

SW680, BT474, Jurkat and K562 cells

WB Recommended dilution:

500-2000