兔抗PPM1M多克隆抗体

Background:

PPM1M is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase was identified as an interacting protein of Rho guanine nucleotide exchange factors (PIX). PIX proteins are regulators of p21/Cdc42/Rac1-activated kinase 1 (PAK1), a protein kinase mediating biological effects downstream of Rho GTPases. This phosphatase has been shown to block the effects of PAK, and thus inhibit actin stress fiber breakdown and morphological changes driven by cell division cycle 42 (CDC42).

Applications:

ELISA, IHC

Name of antibody:

PPM1M

Immunogen:

Fusion protein of human PPM1M

Full name:

protein phosphatase, Mg2+/Mn2+ dependent 1M

Synonyms:

PP2CE; PP2Ceta; PP2C-eta

SwissProt:

Q96MI6

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and Human tonsil

IHC Recommend dilution:

100-300