兔抗pan CDH多克隆抗体

Background:

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.

Applications:

ELISA, IHC

Name of antibody:

pan CDH

Immunogen:

Synthetic peptide of human pan CDH

Full name:

pan-cadherin

SwissProt:

P12830

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human cervical cancer and Human lung cancer

IHC Recommend dilution:

25-100