兔抗NOTCH3多克隆抗体

Background:

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Applications:

ELISA, WB, IHC

Name of antibody:

NOTCH3

Immunogen:

Synthetic peptide of human NOTCH3

Full name:

Notch 3

Synonyms：

CASIL, CADASIL

SwissProt:

Q9UM47

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human colon cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

244 kDa

WB Positive control:

Human colon cancer tissue

WB Recommended dilution:

200-1000