兔抗ANPEP多克隆抗体

Background:

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS.

Applications:

ELISA, IHC

Name of antibody:

ANPEP

Immunogen:

Synthetic peptide of human ANPEP

Full name:

alanyl (membrane) aminopeptidase

Synonyms:

APN; CD13; LAP1; P150; PEPN; GP150

SwissProt:

P15144

IHC positive control:

Human gastric cancer and human thyroid cancer

IHC Recommend dilution:

100-300