兔抗ERG多克隆抗体

Background:

This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Applications:

ELISA, WB, IHC

Name of antibody:

ERG

Immunogen:

Fusion protein of human ERG

Full name:

V-ets erythroblastosis virus E26 oncogene homolog (avian)

Synonyms：

p55; erg-3

SwissProt:

P11308

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human colon cancer and Human lung cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

54 kDa

WB Positive control:

293T cells

WB Recommended dilution:

500-2000