兔抗EMP2多克隆抗体

Background:

EMP-2 (epithelial membrane protein 2), also known as XMP, is a 167 amino acid multi-pass membrane protein that contains four-transmembrane domains and belongs to the GAS3/PMP22 (growth arrest-specific-3/peripheral myelin protein-22) family. Localized to lipid raft domains in the plasma membrane, EMP-2 regulates the expression of several target proteins and is necessary for blastocyst implantation in the uterine endometrium. Specifically, EMP-2 mediates blastocyst implantation by controlling the cell membrane expression of MHC and glycosylphosphatidylinositol-anchored proteins, as well as Integrins and caveolin-1. In adult tissues, EMP-2 is expressed in heart, lung, ovary and intestine, while fetal expression is highest in kidney, brain and liver. Overexpression of EMP-2 is associated with endometrial adenocarcinoma, suggesting a possible role for EMP-2 in tumorigenesis.

Applications:

ELISA, IHC

Name of antibody:

EMP2

Immunogen:

Synthetic peptide of human EMP2

Full name:

epithelial membrane protein 2

Synonyms：

XMP

SwissProt:

P54851

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer and Human ovarian cancer

IHC Recommend dilution:

50-200