兔抗CTLA4多克隆抗体

Background:

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Applications:

ELISA, IHC

Name of antibody:

CTLA4

Immunogen:

Synthetic peptide of human CTLA4

Full name:

cytotoxic T-lymphocyte associated protein 4

Synonyms:

CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3

SwissProt:

P16410

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and Human ovarian cancer

IHC Recommend dilution:

25-100