兔抗CSTB多克隆抗体

Background:

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).

Applications:

ELISA, IHC

Name of antibody:

CSTB

Immunogen:

Synthetic peptide of human CSTB

Full name:

cystatin B (stefin B)

Synonyms：

PME; ULD; CST6; EPM1; STFB; EPM1A

SwissProt:

P04080

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human cervical cancer and Human liver cancer

IHC Recommend dilution:

50-200