兔抗CST6多克隆抗体

Background:

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype.

Applications:

ELISA, IHC

Name of antibody:

CST6

Immunogen:

Fusion protein of human CST6

Full name:

cystatin E/M

SwissProt:

Q15828

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human ovarian cancer and human liver cancer

IHC Recommend dilution:

50-200