| Background: | Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. | 
| Applications: | ELISA, IHC | 
| Name of antibody: | CHRNA10 | 
| Immunogen: | Synthetic peptide of human CHRNA10 | 
| Full name: | cholinergic receptor, nicotinic, alpha 10 (neuronal) | 
| Synonyms: | no | 
| SwissProt: | Q9GZZ6 | 
| ELISA Recommended dilution: | 2000-5000 | 
| IHC positive control: | Human colon cancer and Human lung cancer | 
| IHC Recommend dilution: | 25-100 | 
	
	
	
	 
 
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 021-54845833/15800441009
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