小鼠抗RELA单克隆抗体

Background:

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.

Applications:

WB, IHC

Name of antibody:

RELA

Immunogen:

Fusion protein of human RELA

Full name:

v-rel avian reticuloendotheliosis viral oncogene homolog A

Synonyms:

p65; NFKB3

SwissProt:

Q04206

IHC positive control:

Human tonsil and Human esophagus cancer; Human thyroid cancer and Human liver cancer

IHC Recommend dilution:

100-500

WB Predicted band size:

60 kDa

WB Positive control:

RAW264.7, 231, Hela cell lysates

WB Recommended dilution:

500-2000