小鼠抗RAB3IP单克隆抗体

Background:

Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.

Applications:

WB

Name of antibody:

RAB3IP

Immunogen:

Fusion protein of human RAB3IP

Full name:

RAB3A interacting protein

Synonyms:

RABIN3; RABIN8

SwissProt:

Q96QF0

WB Predicted band size:

53 KD

WB Positive control:

293T, Hela and A431 cell lysates

WB Recommended dilution:

500-2000