小鼠抗PTPRC单克隆抗体

Background:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012].

Applications:

WB, IHC, IF, FC

Name of antibody:

PTPRC

Immunogen:

Fusion protein of human PTPRC

Full name:

protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 1

Synonyms:

B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200

SwissProt:

P08575

IHC positive control:

human lung tissue and human lymph node tissue

IHC Recommend dilution:

100-500

WB Predicted band size:

147 kDa

WB Positive control:

Jurkat cell lysate

WB Recommended dilution:

500-2000