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Background: |
This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
LIG1 |
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Immunogen: |
Fusion protein of human LIG1 |
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Full name: |
ligase I, DNA, ATP-dependent |
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SwissProt: |
P18858 |
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ELISA Recommended dilution: |
2000-10000 |
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IHC positive control: |
Human esophagus cancer and Human breast cancer |
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IHC Recommend dilution: |
100-300 |
